US 11,912,693 B2
Compounds for modulating S1P1 activity and methods of using the same
Philip Michael Pitis, Chesterbrook, PA (US); Robert Eugene Boyd, Chesterbrook, PA (US); Tamara Ann Miskowski Daubert, Chesterbrook, PA (US); Michael John Hawkins, Chesterbrook, PA (US); Guodong Liu, Chesterbrook, PA (US); and Aimee Crombie Speerschneider, Chesterbrook, PA (US)
Assigned to TREVENA, INC., Chesterbrook, PA (US)
Appl. No. 16/613,152
Filed by TREVENA, INC., Chesterbrook, PA (US)
PCT Filed Jun. 12, 2018, PCT No. PCT/US2018/036989
§ 371(c)(1), (2) Date Nov. 13, 2019,
PCT Pub. No. WO2018/231745, PCT Pub. Date Dec. 20, 2018.
Claims priority of provisional application 62/519,575, filed on Jun. 14, 2017.
Prior Publication US 2021/0188826 A1, Jun. 24, 2021
Int. Cl. A61P 25/02 (2006.01); A61P 35/00 (2006.01); C07D 413/14 (2006.01); C07D 413/04 (2006.01); C07D 405/14 (2006.01)
CPC C07D 413/04 (2013.01) [A61P 25/02 (2018.01); A61P 35/00 (2018.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01)] 8 Claims
 
1. A compound having the formula of:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.
 
2. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof.
 
4. The compound of claim 1 having the formula of:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.
 
5. A pharmaceutical composition comprising a compound of claim 4, or a pharmaceutically acceptable salt thereof.