US 11,912,679 B2
Aryl alkynamide derivatives
Junko Maeda, Tokyo (JP); Ikumi Kuriwaki, Tokyo (JP); Kai Kitamura, Tokyo (JP); Yumi Yamashita, Tokyo (JP); Kenichi Kakefuda, Tokyo (JP); Akio Kamikawa, Tokyo (JP); Kenji Negoro, Tokyo (JP); Wataru Hamaguchi, Tokyo (JP); Ryushi Seo, Tokyo (JP); and Jeffrey Ciavarri, Cambridge, MA (US)
Assigned to Astellas Pharma, Inc., Tokyo (JP); and Mitobridge, Inc., Cambridge, MA (US)
Filed by Astellas Pharma, Inc., Tokyo (JP); and Mitobridge, Inc., Cambridge, MA (US)
Filed on Sep. 26, 2023, as Appl. No. 18/372,771.
Application 18/372,771 is a continuation of application No. PCT/US2023/013924, filed on Feb. 27, 2023.
Claims priority of provisional application 63/314,783, filed on Feb. 28, 2022.
Prior Publication US 2024/0018113 A1, Jan. 18, 2024
Int. Cl. C07C 233/69 (2006.01); C07C 233/22 (2006.01); C07C 233/81 (2006.01); C07C 235/42 (2006.01); C07C 237/42 (2006.01); C07C 311/13 (2006.01); C07C 311/46 (2006.01); C07D 205/04 (2006.01); C07D 207/12 (2006.01); C07D 207/16 (2006.01); C07D 207/273 (2006.01); C07D 209/08 (2006.01); C07D 211/48 (2006.01); C07D 211/62 (2006.01); C07D 213/56 (2006.01); C07D 213/75 (2006.01); C07D 231/12 (2006.01); C07D 231/40 (2006.01); C07D 239/26 (2006.01); C07D 279/12 (2006.01); C07D 295/155 (2006.01); C07D 295/16 (2006.01); C07D 295/195 (2006.01); C07D 305/08 (2006.01); C07D 307/22 (2006.01); C07D 309/14 (2006.01); C07D 333/48 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 403/10 (2006.01); C07D 405/10 (2006.01); C07D 487/10 (2006.01)
CPC C07D 295/16 (2013.01) [C07C 233/22 (2013.01); C07C 233/69 (2013.01); C07C 233/81 (2013.01); C07C 235/42 (2013.01); C07C 237/42 (2013.01); C07C 311/13 (2013.01); C07C 311/46 (2013.01); C07D 205/04 (2013.01); C07D 207/12 (2013.01); C07D 207/16 (2013.01); C07D 207/273 (2013.01); C07D 209/08 (2013.01); C07D 211/48 (2013.01); C07D 211/62 (2013.01); C07D 213/56 (2013.01); C07D 213/75 (2013.01); C07D 231/12 (2013.01); C07D 231/40 (2013.01); C07D 239/26 (2013.01); C07D 279/12 (2013.01); C07D 295/155 (2013.01); C07D 295/195 (2013.01); C07D 305/08 (2013.01); C07D 307/22 (2013.01); C07D 309/14 (2013.01); C07D 333/48 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 403/10 (2013.01); C07D 405/10 (2013.01); C07D 487/10 (2013.01)] 19 Claims
 
1. A compound of formula (I) or a salt thereof:

OG Complex Work Unit Chemistry
wherein,
Ring A is phenyl,
Ring B is formula (V):

OG Complex Work Unit Chemistry
X is CH or N,
Ra1, Ra2 and Rb1 are H,
Rb2 is halogeno-C1-6 alkyl,
R1 is H,
R2 is C1-6 alkyl which is substituted by one or two R3,
or, R1 and R2 are linked to each other to form azetidinyl, pyrrolidinyl, piperidinyl or thiomorpholinyl together with the nitrogen atom to which R1 and R2 are attached, wherein the azetidinyl, pyrrolidinyl, piperidinyl or thiomorpholinyl may be optionally substituted with one or two R7,
each R3 is independently —OH or —C(═O)—NH2, and
each R7 is independently —C1-6 alkylene-OH, —OH, —C(═O)—NH2, oxo or imino.