US 11,912,664 B2
Determining small molecule-protein and protein-protein interactions
Christina M. Woo, Cambridge, MA (US); Jinxu Gao, Somerville, MA (US); Yuka Amako, Watertown, MA (US); Chia Fu Chang, Cambridge, MA (US); Zhi Lin, Cambridge, MA (US); and Hung-Yi Wu, Cambridge, MA (US)
Assigned to President and Fellows of Harvard College, Cambridge, MA (US)
Appl. No. 16/620,372
Filed by President and Fellows of Harvard College, Cambridge, MA (US)
PCT Filed Jun. 6, 2018, PCT No. PCT/US2018/036256
§ 371(c)(1), (2) Date Dec. 6, 2019,
PCT Pub. No. WO2018/226828, PCT Pub. Date Dec. 13, 2018.
Claims priority of provisional application 62/651,599, filed on Apr. 2, 2018.
Claims priority of provisional application 62/628,372, filed on Feb. 9, 2018.
Claims priority of provisional application 62/515,846, filed on Jun. 6, 2017.
Prior Publication US 2020/0140388 A1, May 7, 2020
Int. Cl. C07D 229/02 (2006.01); C07D 401/12 (2006.01); C07D 487/14 (2006.01); G01N 33/68 (2006.01)
CPC C07D 229/02 (2013.01) [C07D 401/12 (2013.01); C07D 487/14 (2013.01); G01N 33/6803 (2013.01); G01N 33/6845 (2013.01)] 17 Claims
 
1. A compound of Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
S is thalidomide, lenalidomide, or pomalidomide, or a derivative thereof;
P is

OG Complex Work Unit Chemistry
and
L is a bond,

OG Complex Work Unit Chemistry