US 11,911,999 B2
Plasmonic patch as a universal fluorescence enhancer
Srikanth Singamaneni, St. Louis, MO (US); Jingyi Luan, St. Louis, MO (US); Jeremiah Morrissey, St. Louis, MO (US); and Evan Kharasch, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on May 6, 2022, as Appl. No. 17/662,293.
Application 17/662,293 is a continuation of application No. 16/765,441, granted, now 11,351,760, previously published as PCT/US2018/062599, filed on Nov. 27, 2018.
Claims priority of provisional application 62/590,877, filed on Nov. 27, 2017.
Prior Publication US 2022/0274381 A1, Sep. 1, 2022
Prior Publication US 2023/0249441 A9, Aug. 10, 2023
Int. Cl. B32B 27/06 (2006.01)
CPC B32B 27/06 (2013.01) [B32B 2307/422 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A plasmonic patch for enhancing a fluorescent signal from a fluorescent species, the patch comprising:
a flexible substrate comprising a first material,
a plasmonic nanostructure, and
a spacer comprising a second material;
wherein the plasmonic nanostructure is disposed on a first surface of the flexible substrate,
the spacer is disposed on the first surface of the flexible substrate and covers the plasmonic nanostructure;
the fluorescent species has an excitation wavelength (λex) and an emission wavelength (λem),
the plasmonic nanostructure has a localized surface plasmon resonance (LSPR) wavelength (λLSPR),
a difference between the LSPR wavelength and the excitation wavelength is |Δλ|; and
a density of the nanostructures on the flexible substrate is from 1/μm2 to 200/μm2.