CPC B01J 20/14 (2013.01) [A61L 2/081 (2013.01); B01D 37/02 (2013.01); B01J 20/28004 (2013.01); B01J 20/2805 (2013.01); B01J 20/28016 (2013.01); B01J 20/3028 (2013.01); B65B 55/02 (2013.01); B65D 65/40 (2013.01); C12M 47/02 (2013.01); C12M 47/10 (2013.01); A61L 2202/21 (2013.01)] | 7 Claims |
1. A method for producing a diatomaceous earth composition with a low endotoxin content, comprising the following steps:
(a) providing calcined diatomaceous earth particles;
(b) mixing the calcined diatomaceous earth particles with water in a mass ratio of 1:1.0 to 1:2.0, thereby obtaining an agglomerated mixture of calcined diatomaceous earth particles and water;
(c) sealing the agglomerated mixture of calcined diatomaceous earth particles and water obtained in step (b) in a water-impermeable and γ-sterilizable packaging, thereby obtaining a sealed agglomerated mixture of calcined diatomaceous earth particles and water;
(d) sterilizing the sealed agglomerated mixture of calcined diatomaceous earth particles and water obtained in step (c) by exposure to γ-radiation, thereby obtaining a diatomaceous earth composition with an endotoxin content of equal to or less than 0.5 EU/mL; and
(e) optionally removing the packaging from the diatomaceous earth composition obtained in step (d).
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