US 11,911,738 B2
Systems and methods having an analyzer for use in preparing particles
Siew Keong Loke, Singapore (SG); and Kit Ying Soo, Singapore (SG)
Assigned to MATRALIX PTE LTD, Singapore (SG)
Filed by Matralix Pte Ltd, Singapore (SG)
Filed on Aug. 30, 2022, as Appl. No. 17/899,317.
Application 17/899,317 is a division of application No. 16/846,201, filed on Apr. 10, 2020, granted, now 11,491,454.
Application 16/846,201 is a continuation of application No. 16/006,474, filed on Jun. 12, 2018, granted, now 10,639,607, issued on May 5, 2020.
Claims priority of provisional application 62/521,062, filed on Jun. 16, 2017.
Prior Publication US 2022/0410110 A1, Dec. 29, 2022
Int. Cl. B01J 13/04 (2006.01); A61K 8/11 (2006.01); A61K 8/92 (2006.01); A61Q 19/00 (2006.01); C08L 91/06 (2006.01)
CPC B01J 13/04 (2013.01) [A61K 8/11 (2013.01); A61K 8/927 (2013.01); A61Q 19/00 (2013.01); C08L 91/06 (2013.01); A61K 2800/10 (2013.01); A61K 2800/412 (2013.01); C08L 2207/53 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A system for forming particles, the system comprising:
a conduit with a conduit lumen having a first cross-sectional dimension and having a conduit inlet and a conduit outlet;
an extruder tube having an extruder inlet and an extruder orifice as an extruder outlet located within the conduit, the extruder orifice having a second cross-sectional dimension that is smaller than the first cross-sectional dimension;
a particle collector fluidly coupled with the conduit outlet, wherein the particle collector has a collector inlet, a product collector outlet, and a waste outlet;
a particle analyzer operatively coupled with the particle collector so as to be capable of analyzing particles within the particle analyzer, wherein the particle analyzer includes a camera;
a control system having a computer processor adapted to control the system,
wherein the control system is configured to perform a pre-programmed particle formation protocol comprising:
flow carrier fluid through the conduit at a pre-programmed flow rate;
flow extruding material through the extruder orifice at a pre-programmed flow rate into the conduit with the carrier fluid;
provide the temperature gradient to the particle collector having a preprogrammed first temperature at the collector inlet and a preprogramed temperature at the collector outlet;
form hardened particles;
select a waste portion of the hardened particles for waste; and
select a product portion of the hardened particles for products.