US 11,911,719 B2
Devices and methods for the integrated filtration, drying, and mechanical processing of active pharmaceutical ingredients
David Brancazio, Cambridge, MA (US); Allan S. Myerson, Cambridge, MA (US); Mohammad A. Azad, Greensboro, NC (US); Gregory J. Hammersmith, Windsor, CT (US); Gerard Capellades Mendez, Cambridge, MA (US); Clemence Neurohr, Cambridge, MA (US); Kersten Rapp, Medway, MA (US); and Naomi Elizabeth Barbara Briggs, Rockville, MD (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Jul. 20, 2020, as Appl. No. 16/933,158.
Claims priority of provisional application 62/904,240, filed on Sep. 23, 2019.
Claims priority of provisional application 62/903,571, filed on Sep. 20, 2019.
Prior Publication US 2021/0086112 A1, Mar. 25, 2021
Int. Cl. B01D 29/86 (2006.01); A61K 31/496 (2006.01); B01D 29/05 (2006.01); B01D 29/60 (2006.01); B01D 35/18 (2006.01); A61J 3/10 (2006.01); B01D 29/075 (2006.01)
CPC B01D 29/86 (2013.01) [A61K 31/496 (2013.01); B01D 29/05 (2013.01); B01D 29/608 (2013.01); B01D 35/18 (2013.01); A61J 3/10 (2013.01); B01D 29/075 (2021.08); B01D 2201/204 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method, comprising:
rotating an edge comprising a plurality of protrusions extending toward a filtration medium such that the edge sweeps at least a portion of a facial area of the filtration medium in a clockwise direction; and
rotating the edge such that the edge sweeps at least a portion of the facial area of the filtration medium in a counterclockwise direction;
wherein the edge comprises at least 20 protrusions having a protruding dimension of greater than or equal to 1 mm and less than or equal to 2 cm;
wherein the at least 20 protrusions have an average spacing of greater than or equal to 1 mm and less than or equal to 1 cm;
wherein the rotating in the clockwise direction and/or the counterclockwise direction breaks up solid material having maximum cross-sectional dimensions of greater than or equal to 100 micrometers and less than or equal to 10 millimeters, forming a powder; and
wherein at least 90%, by mass, of the powder has a particle size of less than 500 micrometers.