US 11,911,631 B2
Tumor bed implant for multimodality treatment of at risk tissue surrounding a resection cavity
Paul Stauffer, Philadelphia, PA (US); Voichita Bar-ad, Wynnewood, PA (US); Mark Hurwitz, Narberth, PA (US); Adam Luginbuhl, Gulph Mills, PA (US); Michele Marcolongo, Aston, PA (US); Dario Rodrigues, Philadelphia, PA (US); David Cognetti, Penn Valley, PA (US); Joseph Curry, Wynewood, PA (US); and Katsiaryna Prudnikova, Huntingdon Valley, PA (US)
Assigned to Thomas Jefferson University, Philadelphia, PA (US); and Drexel University, Philadelphia, PA (US)
Appl. No. 16/086,733
Filed by Thomas Jefferson University, Philadelphia, PA (US); and Drexel University, Philadelphia, PA (US)
PCT Filed Mar. 31, 2017, PCT No. PCT/US2017/025523
§ 371(c)(1), (2) Date Sep. 20, 2018,
PCT Pub. No. WO2017/173352, PCT Pub. Date Oct. 5, 2017.
Claims priority of provisional application 62/315,839, filed on Mar. 31, 2016.
Prior Publication US 2019/0099618 A1, Apr. 4, 2019
Int. Cl. A61N 5/10 (2006.01); A61N 2/00 (2006.01); A61K 41/00 (2020.01); A61K 51/12 (2006.01); A61B 5/00 (2006.01); A61B 5/06 (2006.01); A61N 5/02 (2006.01); A61B 5/01 (2006.01)
CPC A61N 5/1015 (2013.01) [A61B 5/06 (2013.01); A61B 5/6852 (2013.01); A61K 41/0052 (2013.01); A61K 51/1213 (2013.01); A61N 2/002 (2013.01); A61N 2/004 (2013.01); A61N 5/025 (2013.01); A61N 5/1027 (2013.01); A61B 5/01 (2013.01); A61B 5/4848 (2013.01); A61N 2005/1024 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A multimodality simultaneous thermobrachytherapy treatment system comprising:
an outer biocompatible expandable balloon configured to fill a resection cavity;
an inner biocompatible expandable balloon disposed within a cavity defined by the outer biocompatible expandable balloon;
magnetic material capable of insertion within the outer biocompatible expandable balloon for heating a tissue surrounding a resection cavity wall;
a biocompatible sheath;
at least a first catheter, a second catheter, and an internal catheter positioned within the biocompatible sheath:
the first catheter adapted and configured to extend from outside of the patient to an interior of the inner biocompatible expandable balloon to convey a fluid to the interior of the inner biocompatible expandable balloon,
the second catheter adapted and configured to extend from outside the patient to an interior of the outer biocompatible expandable balloon to convey the magnetic material to the interior of the outer biocompatible expandable balloon, and
the internal catheter adapted and configured:
to extend along the biocompatible sheath, from outside of the patient through the interior of the inner biocompatible expandable balloon, and
for coupling with a remote afterloader for insertion and movement of a radiation source within the internal catheter;
a collar external to the sheath, the collar comprising suture holes adapted and configured for fixation to a tissue surface external to the patient; and
a non-contacting induction coil configured to apply a magnetic field surrounding the outer biocompatible balloon simultaneously with the movement of the radiation source within the internal catheter, the magnetic field adapted and configured to be:
generated external to the patient;
inductively coupled to and thereby heat the magnetic material to produce a substantially non-ablative temperature distribution of about 40-45° C. for about 30-60 mins in the tissue surrounding the resection cavity wall when the magnetic material is inserted within the outer biocompatible expandable balloon; and
applied at a frequency in the range of about 50 kHz to about 500 kHz;
wherein the inner biocompatible expandable balloon and the outer biocompatible expandable balloon are adapted and configured to be used at the same time.