US 11,911,553 B2
Systems and methods for concentrating cells with a syringe and a centrifuge
Kyungyoon Min, Kildeer, IL (US); Christopher J. Wegener, Libertyville, IL (US); and Alexander Dodge, Lincolnshire, IL (US)
Assigned to Fenwal, Inc., Lake Zurich, IL (US)
Filed by Fenwal, Inc., Lake Zurich, IL (US)
Filed on Jun. 17, 2019, as Appl. No. 16/442,671.
Claims priority of provisional application 62/694,601, filed on Jul. 6, 2018.
Prior Publication US 2020/0009312 A1, Jan. 9, 2020
Int. Cl. A61M 1/36 (2006.01); A61M 1/02 (2006.01); B01L 3/00 (2006.01)
CPC A61M 1/3692 (2014.02) [A61M 1/0272 (2013.01); A61M 1/0281 (2013.01); A61M 1/3693 (2013.01); A61M 1/362227 (2022.05); A61M 1/362265 (2022.05); B01L 3/502 (2013.01); A61M 1/36224 (2022.05); B01L 2400/0409 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A system for concentrating cells, comprising:
a syringe comprising a lumen and an axial end comprising a port and a radial end closed to liquid flow, wherein a plunger divides the axial and radial ends, and wherein the syringe is configured to hold a cellular suspension;
a filter disposed at the radial end configured to maintain sterility of the syringe;
a cap comprising a vent disposed at the radial end; and
a syringe holder comprising an inner shell configured to fit concentrically within an outer shell having an end forming a recess when the inner shell is fully inserted into the outer shell, wherein
the syringe holder is configured to fit in a cavity of a centrifuge rotor having an axis of rotation and the syringe holder is configured to receive the syringe containing the cellular suspension with the axial end disposed towards an axial direction relative to the axis of rotation and the radial end disposed towards a radial direction relative to the axis of rotation, and
the plunger is configured to be actuated towards the axial end by air pressure being applied into the radial end and the plunger is configured to be actuated towards the radial end by a vacuum being applied into the radial end.