CPC A61M 1/3689 (2014.02) [A61M 1/1698 (2013.01); A61M 1/3623 (2022.05); A61M 1/3626 (2013.01); A61M 1/3653 (2013.01); A61M 1/3679 (2013.01); A61M 39/105 (2013.01); C12M 21/08 (2013.01); A61M 1/3496 (2013.01); A61M 1/3672 (2013.01); A61M 2202/0415 (2013.01); A61M 2205/3368 (2013.01)] | 14 Claims |
1. A combined bio-artificial liver support system, comprising a plurality of branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end, wherein by means of three-way devices, the first plasma separation branch tube is connected to inlet ends of the biological purification branch tube and the non-biological purification branch tube, an outlet end of the non-biological purification branch tube is connected to the biological purification branch tube, and the outlet end of the non-biological purification branch tube is connected to the plasma return branch tube, each of the three-way devices comprises a three-way joint and branches respectively connected to the three-way joint, and at least two said branches are respectively provided with a flow restricting member and a coupling member.
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