US 11,911,552 B2
Combined bio-artificial liver support system
Yi Gao, Guangdong (CN); Mingxin Pan, Guangdong (CN); Lei Feng, Guangdong (CN); Yang Li, Guangdong (CN); Lei Cai, Guangdong (CN); Guolin He, Guangdong (CN); Jun Weng, Guangdong (CN); and Qing Peng, Guangdong (CN)
Assigned to Southern Medical University Zhujiang Hospital, (CN)
Appl. No. 16/966,101
Filed by Southern Medical University Zhujiang Hospital, Guangdong (CN)
PCT Filed Mar. 23, 2018, PCT No. PCT/CN2018/080285
§ 371(c)(1), (2) Date Jul. 30, 2020,
PCT Pub. No. WO2019/148611, PCT Pub. Date Aug. 8, 2019.
Claims priority of application No. 201810102479.8 (CN), filed on Feb. 1, 2018.
Prior Publication US 2021/0030943 A1, Feb. 4, 2021
Int. Cl. A61M 1/16 (2006.01); A61M 1/34 (2006.01); A61M 1/36 (2006.01); A61M 39/10 (2006.01); C12M 3/00 (2006.01)
CPC A61M 1/3689 (2014.02) [A61M 1/1698 (2013.01); A61M 1/3623 (2022.05); A61M 1/3626 (2013.01); A61M 1/3653 (2013.01); A61M 1/3679 (2013.01); A61M 39/105 (2013.01); C12M 21/08 (2013.01); A61M 1/3496 (2013.01); A61M 1/3672 (2013.01); A61M 2202/0415 (2013.01); A61M 2205/3368 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A combined bio-artificial liver support system, comprising a plurality of branch tubes that are connected in sequence: a blood input branch tube, an upstream tail end of which is set as a blood input end, a first plasma separation branch tube comprising at least a first plasma separator, a non-biological purification branch tube comprising at least a plasma perfusion device and a bilirubin adsorber, a biological purification branch tube comprising at least a hepatocyte culture cartridge assembly, and a plasma return branch tube, a downstream tail end of which is set as a blood output end, wherein by means of three-way devices, the first plasma separation branch tube is connected to inlet ends of the biological purification branch tube and the non-biological purification branch tube, an outlet end of the non-biological purification branch tube is connected to the biological purification branch tube, and the outlet end of the non-biological purification branch tube is connected to the plasma return branch tube, each of the three-way devices comprises a three-way joint and branches respectively connected to the three-way joint, and at least two said branches are respectively provided with a flow restricting member and a coupling member.