US 11,911,522 B2
Process for the continuous manufacture of a polyisobutylene based transdermal patch
Russell Adam Baird, Berkeley Lake, GA (US); Brad L. Barnett, Swanton, VT (US); and Russell D. Beste, Burlington, VT (US)
Assigned to Mylan Inc., Canonsburg, PA (US)
Filed by Mylan Inc., Canonsburg, PA (US)
Filed on Apr. 27, 2020, as Appl. No. 16/859,313.
Application 16/859,313 is a continuation of application No. 12/838,919, filed on Jul. 19, 2010, granted, now 10,632,082.
Claims priority of provisional application 61/271,398, filed on Jul. 21, 2009.
Prior Publication US 2020/0253886 A1, Aug. 13, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. C08L 23/22 (2006.01); A61K 9/70 (2006.01); C09J 123/22 (2006.01)
CPC A61K 9/7053 (2013.01) [C09J 123/22 (2013.01); C08L 23/22 (2013.01); C08L 2205/02 (2013.01); C08L 2666/06 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A continuous process for the production of an adhesive composition comprising:
a) pre-processing a non-granulated high molecular weight polyisobutylene (HMW PIB) having a molecular weight ranging from about 200,000 g/mol to about 800,000 g/mol in a single-screw extruder to form a bulk BMW PIB material, wherein said bulk BMW PIB material is in a compressed, continuous feed form;
b) extruding said bulk HMW PIB material in an extruding apparatus, wherein said HMW PIB is extruded;
c) simultaneously extruding said extruded HMW PIB with low molecular weight polyisobutylene (LMW PIB) in said extruding apparatus to produce high shear so as to form an extruded melt, wherein a ratio of the amount of HMW PIB to LMW PIB in said melt ranges from about 50:50 to about 70:30;
d) adding an active pharmaceutical ingredient (API) to said extruded melt to produce an extruded API/PIB melt; and
e) discharging said extruded API/PIB melt to a die to form said adhesive composition, wherein said adhesive composition comprises about 93% to about 97% PIB and about 3% to about 7% API.