CPC A61K 9/2886 (2013.01) [A61K 9/5042 (2013.01); A61K 9/5073 (2013.01); A61K 31/4425 (2013.01); A61K 9/2866 (2013.01)] | 20 Claims |
1. A gastroretentive dosage form comprising a core, and a permeable elastic membrane comprising at least one orifice and surrounding the core,
wherein the core comprises pyridostigmine or a pharmaceutically acceptable salt thereof, and a gas generating agent,
wherein the permeable elastic membrane comprises a copolymer based on ethyl acrylate, methyl methacrylate, and trimethylammonioethyl methacrylate chloride,
wherein the copolymer is present in an amount of from about 70 wt % to about 95 wt %, based on the total weight of the membrane, and
wherein the dosage form floats in 40 minutes or less in about 200 ml of a dissolution medium comprising about 50 mM of pH 4.5 buffer and about 100 mM sodium chloride, measured using Rotating Bottle method at about 5 rpm and about 37° C.
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