CPC A61K 9/2077 (2013.01) [A61K 9/0053 (2013.01); A61K 9/209 (2013.01); A61K 9/2031 (2013.01); A61K 9/2054 (2013.01); A61K 9/2086 (2013.01); A61K 9/28 (2013.01); A61K 31/485 (2013.01)] | 20 Claims |
1. A method of treating pain in a subject, comprising:
administering to the subject a solid controlled release dosage form, the solid controlled release dosage form comprising:
a core comprising a first portion of an opioid analgesic dispersed in a first matrix material, wherein the opioid analgesic comprises oxycodone, a pharmaceutically acceptable salt thereof or combinations thereof; and
a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material,
wherein the dosage form further comprises acetaminophen;
wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37° C.
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