US 11,911,488 B2
Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy
Martin G. Pomper, Baltimore, MD (US); Ronnie C. Mease, Fairfax, VA (US); Sangeeta Ray, Ellicott City, MD (US); Ying Chen, Lutherville-Timonium, MD (US); and Xing Yang, Balitmore, MD (US)
Assigned to THE JOHNS HOPKINS UNIVERSTY, Baltimore, MD (US)
Filed by The Johns Hopkins University, Baltimore, MD (US)
Filed on Aug. 4, 2020, as Appl. No. 16/984,415.
Application 16/984,415 is a continuation of application No. 15/521,149, granted, now 10,736,974, previously published as PCT/US2015/056909, filed on Oct. 22, 2015.
Claims priority of provisional application 62/067,185, filed on Oct. 22, 2014.
Prior Publication US 2020/0360542 A1, Nov. 19, 2020
Int. Cl. A61K 51/04 (2006.01); A61K 41/00 (2020.01); A61K 49/00 (2006.01); C07D 213/82 (2006.01); C07D 209/12 (2006.01); C07C 271/22 (2006.01); C07C 275/16 (2006.01); C07C 323/62 (2006.01)
CPC A61K 51/0402 (2013.01) [A61K 41/0057 (2013.01); A61K 49/0002 (2013.01); A61K 49/0021 (2013.01); A61K 49/0032 (2013.01); A61K 49/0041 (2013.01); A61K 49/0052 (2013.01); A61K 51/0455 (2013.01); C07C 271/22 (2013.01); C07C 275/16 (2013.01); C07C 323/62 (2013.01); C07D 209/12 (2013.01); C07D 213/82 (2013.01); A61K 49/0017 (2013.01); A61K 49/0019 (2013.01)] 4 Claims
 
1. A compound of formula (Ia′):

OG Complex Work Unit Chemistry
wherein:
W is selected from H and F; and
Z is selected from Br, F, I, 125I and 18F.