CPC A61K 47/65 (2017.08) [A61K 45/06 (2013.01); A61K 47/6425 (2017.08); A61K 47/6865 (2017.08); A61P 35/00 (2018.01)] | 6 Claims |
1. A compound represented by formula (I)
![]() wherein
R1 is C1-C5 alkyl, N3, OH, SH, ONH2, NH2, CO2H,
![]() R2 is the side chain residue of an amino acid selected from the group consisting of alanine, β-alanine, γ-aminobutyric acid, arginine, asparagine, aspartic acid, γ-carboxyglutamic acid, citrulline, cysteine, glutamic acid, glutamine, glycine, histidine, isoleucine, leucine, lysine, methionine, norleucine, norvaline, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine;
n is 2 3, 4, or 5;
![]() comprising a polypeptide whose bond to
![]() is cleavable by cathepsin B;
R3 is NH,
![]() R4 is
![]() L is the residue of a bioactive molecule of the formula L-R3H; and
X is spacer group.
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