US 11,911,443 B2
Fusion proteins with extended serum half life
Ari-Angel Porgador, Lehavim (IL); David Ben-Menahem, Omer (IL); and Roee Atlas, Givataim (IL)
Assigned to THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., Beer Sheva (IL); and B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, Beer Sheva (IL)
Filed by THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD., Beer Sheva (IL); and B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY, Beer Sheva (IL)
Filed on Oct. 11, 2021, as Appl. No. 17/498,262.
Application 17/498,262 is a continuation of application No. 16/316,410, granted, now 11,141,463, previously published as PCT/IL2017/050788, filed on Jul. 11, 2017.
Claims priority of provisional application 62/421,400, filed on Nov. 14, 2016.
Claims priority of provisional application 62/360,524, filed on Jul. 11, 2016.
Prior Publication US 2022/0023388 A1, Jan. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/19 (2006.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); A61K 47/64 (2017.01); C07K 14/55 (2006.01); C07K 14/59 (2006.01); C07K 14/61 (2006.01); C07K 19/00 (2006.01)
CPC A61K 38/19 (2013.01) [A61K 38/18 (2013.01); A61K 47/642 (2017.08); C07K 14/55 (2013.01); C07K 14/59 (2013.01); C07K 14/61 (2013.01); C07K 19/00 (2013.01); A61K 38/00 (2013.01); C07K 2319/31 (2013.01); C07K 2319/33 (2013.01)] 18 Claims
 
1. A method of extending the biological half-life of a protein of interest, comprising the step of providing a chimera by attaching at least one peptide comprising 20 to 70 contiguous amino acid residues from amino acids 130 to 199 of SEQ ID NO: 1 to a protein of interest, thereby extending the biological half-life of a protein of interest.