US 11,911,405 B2
Methods of selectively modulating gastrointestinal microbial growth
Stephane Duval, Carspach (FR); John Michael Geremia, Watertown, MA (US); Lisa Ann Laprade, Dedham, MA (US); April Waguespack-Levy, Ankeny, IA (US); Estefania Perez Calvo, Rosenau (FR); Ghislain Schyns, Waltham, MA (US); Viviane Verlhac, Dietwiller (FR); and Joshua Thomas Claypool, Cambridge, MA (US)
Assigned to DSM IP ASSETS B.V., Heerlen (NL)
Appl. No. 17/292,132
Filed by DSM IP Assets B.V., Heerlen (NL)
PCT Filed Nov. 8, 2019, PCT No. PCT/US2019/060488
§ 371(c)(1), (2) Date May 7, 2021,
PCT Pub. No. WO2020/097472, PCT Pub. Date May 14, 2020.
Claims priority of provisional application 62/757,438, filed on Nov. 8, 2018.
Claims priority of provisional application 62/757,439, filed on Nov. 8, 2018.
Prior Publication US 2021/0393658 A1, Dec. 23, 2021
Int. Cl. A61K 31/702 (2006.01); A23K 20/163 (2016.01); A23K 50/30 (2016.01); A23K 50/75 (2016.01)
CPC A61K 31/702 (2013.01) [A23K 20/163 (2016.05); A23K 50/30 (2016.05); A23K 50/75 (2016.05)] 8 Claims
 
1. A method of increasing the body weight of an animal, the method comprising:
administering a nutritional composition comprising a base nutritional composition and a synthetic oligosaccharide preparation to an animal,
wherein said synthetic oligosaccharide preparation comprises at least n fractions of oligosaccharides each having a distinct degree of polymerization selected from 1 to n (DP1 to DPn fractions), wherein n is an integer greater than 3; and wherein each of a DP1 and DP2 fraction independently comprises from about 0.5% to about 15% of anhydro-subunit containing oligosaccharides by relative abundance as determined by mass spectrometry, and
wherein the body weight of said animal is increased relative to the body weight of said animal prior to said administering said nutritional composition to said animal, and wherein the increase in the body weight of said animal is a larger increase relative to an increase in body weight of a comparable control animal administered a comparable nutritional composition lacking said oligosaccharide preparation.