CPC A61K 31/616 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/19 (2013.01); A61K 47/26 (2013.01)] | 27 Claims |
1. A method of providing aspirin therapy, comprising:
a) providing a lyophilized mixture comprising crystalline aspirin in free acid form, a bulking agent and a surfactant, wherein the lyophilized mixture is made without adding any basifying agent;
b) reconstituting the lyophilized mixture with water containing a basifying agent present in an amount sufficient to provide the resultant aspirin solution with a pH of at least about 5.5, wherein the water containing the basifying agent is separate from the crystalline aspirin prior to reconstituting; and
c) parenterally administering an effective amount of the aspirin solution resulting from step b) to a mammal in need thereof.
|