US 11,911,349 B2
Rapidly improving vascular conditions by administering vitamin K
Stefan Chlopicki, Cracow (PL); Katarzyna Maresz, Cracow (PL); and Anna Bar, Przemysl (PL)
Assigned to NATTOPHARMA AS, Oslo (NO)
Filed by NATTOPHARMA AS, Oslo (NO)
Filed on Apr. 1, 2019, as Appl. No. 16/372,173.
Claims priority of provisional application 62/816,499, filed on Mar. 11, 2019.
Claims priority of provisional application 62/650,674, filed on Mar. 30, 2018.
Prior Publication US 2019/0328683 A1, Oct. 31, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/122 (2006.01); A61P 9/10 (2006.01); A61P 9/14 (2006.01); A61K 31/592 (2006.01); A61K 31/593 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/122 (2013.01) [A61K 31/592 (2013.01); A61K 31/593 (2013.01); A61P 9/10 (2018.01); A61P 9/14 (2018.01); A61K 45/06 (2013.01)] 8 Claims
 
1. A method of increasing endothelial nitric oxide production in a human before development of atherosclerosis comprising:
determining a first nitrite plasma concentration in the human;
administering to the human an effective amount of vitamin K2 for a period of less than 4 weeks at an amount of 150 to 500 μg/day; and
determining a second nitrite plasma concentration in the human after the period.