US 11,911,301 B2
Polymer coatings containing drug powder of controlled morphology
Charles Douglas Taylor, Franklinton, NC (US); James B. McClain, Ocracoke, NC (US); Mike Cole, Raleigh, NC (US); James P. DeYoung, Dallas, TX (US); and Clint Smoke, Raleigh, NC (US)
Assigned to Micell Medtech Inc., Pine Plains, NY (US)
Filed by Micell Technologies, Inc., Durham, NC (US)
Filed on Jan. 25, 2021, as Appl. No. 17/157,115.
Application 13/605,904 is a division of application No. 11/995,687, granted, now 8,298,565, issued on Oct. 30, 2012, previously published as PCT/US2006/027321, filed on Jul. 14, 2006.
Application 17/157,115 is a continuation of application No. 15/705,489, filed on Sep. 15, 2017, granted, now 10,898,353, issued on Jan. 26, 2021.
Application 15/705,489 is a continuation of application No. 14/262,163, filed on Apr. 25, 2014, granted, now 9,827,117, issued on Nov. 28, 2017.
Application 14/262,163 is a continuation of application No. 13/605,904, filed on Sep. 6, 2012, granted, now 8,758,429, issued on Jun. 24, 2014.
Claims priority of provisional application 60/745,733, filed on Apr. 26, 2006.
Claims priority of provisional application 60/745,731, filed on Apr. 26, 2006.
Claims priority of provisional application 60/771,725, filed on Feb. 8, 2006.
Claims priority of provisional application 60/771,066, filed on Feb. 7, 2006.
Claims priority of provisional application 60/752,338, filed on Dec. 20, 2005.
Claims priority of provisional application 60/699,650, filed on Jul. 15, 2005.
Prior Publication US 2021/0161687 A1, Jun. 3, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/82 (2013.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01)
CPC A61F 2/82 (2013.01) [A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61F 2210/0076 (2013.01); A61F 2250/0067 (2013.01); A61L 2300/416 (2013.01); A61L 2300/426 (2013.01); A61L 2300/606 (2013.01); A61L 2300/63 (2013.01); A61L 2420/08 (2013.01); Y10T 428/264 (2015.01); Y10T 428/265 (2015.01); Y10T 428/31507 (2015.04); Y10T 428/31544 (2015.04); Y10T 428/31551 (2015.04); Y10T 428/31663 (2015.04); Y10T 428/31786 (2015.04); Y10T 428/31935 (2015.04); Y10T 428/31938 (2015.04)] 19 Claims
 
1. A coating method, comprising the steps of:
discharging particles of a pharmaceutical agent in dry powder form;
discharging particles of a polymer;
depositing the polymer and pharmaceutical agent particles to form a coating; and
sintering the coating by treating the coating with a compressed gas that is a non-solvent for both the polymer and the pharmaceutical agent under conditions that do not substantially modify the morphology of the pharmaceutical agent particles,
wherein the pharmaceutical agent particles are deposited on a substrate in crystalline form.