	US 11,911,203 B2
	Method and system for registering intra-object data with extra-object data
Jean-Paul Aben, Limbricht (NL); Chris Bouwman, Oirsbeek (NL); and Bas Weijers, Maasmechelen (BE)
Assigned to Pie Medical Imaging B.V., Maastricht (NL)
Filed by Pie Medical Imaging B.V., Maastricht (NL)
Filed on Mar. 22, 2021, as Appl. No. 17/208,373.
Claims priority of application No. 20165750 (EP), filed on Mar. 26, 2020.
Prior Publication US 2021/0298708 A1, Sep. 30, 2021
Int. Cl. A61B 6/00 (2006.01); A61B 5/33 (2021.01)

CPC A61B 6/5235 (2013.01) [A61B 5/33 (2021.01); A61B 6/481 (2013.01); A61B 6/487 (2013.01); A61B 6/504 (2013.01); A61B 6/5217 (2013.01)]

26 Claims

1. A method for correlating intraluminal data with x-ray image data, comprising:

providing x-ray image data of a tubular organ;

providing intraluminal data of the tubular organ;

synchronizing the x-ray image data with the intraluminal data based on a cardiac cycle extracted from an available input signal and/or the x-ray image data and/or the intraluminal data to match x-ray image data with intraluminal data in a specific cardiac phase; and

co-registering x-ray image data with intraluminal data by creating a cumulative image at the specific cardiac phase which reconstructs a path followed by an intraluminal wire used for acquiring the intraluminal data to link the intraluminal data to spatial locations of the path followed by the intraluminal wire within the x-ray image;

wherein the coregistering involves determining a start of pullback of the intraluminal wire by analyzing a movement curve created by computing absolute distance of the intraluminal wire between a reference image frame and remaining image frames of the x-ray image data.

21. A system for registering x-ray images with intraluminal data of a tubular organ comprising:

an angiographic imaging apparatus for obtaining x-ray images of the tubular organ;

an intravascular apparatus for obtaining intraluminal data of the tubular organ; and

a combination device comprising a data processing module, and interface elements for receiving x-ray images from the angiographic imaging apparatus and intraluminal data from the intravascular apparatus,

wherein the data processing module is configured to synchronize the x-ray image data with the intraluminal data based on a cardiac cycle extracted from an available input signal and/or the x-ray image data and/or the intraluminal data to match x-ray image data with intraluminal data in a specific cardiac phase and co-register the x-ray image data with intraluminal data by creating a cumulative image at the specific cardiac phase which reconstructs a path followed by an intraluminal wire used for acquiring the intraluminal data to link the intraluminal data to spatial locations of the path followed by the intraluminal wire within the x-ray image, wherein the co-registration of the x-ray image data with the intraluminal data involves determining a start of pullback of the intraluminal wire by analyzing a movement curve created by computing absolute distance of the intraluminal wire between a reference image frame and remaining image frames of the x-ray image data.