US 11,911,139 B2
System and method for automatic perfusion measurement
Morten Toft Lund, Copenhagen N (DK); and Mads Holst Aagaard Madsen, Copenhagen Ø (DK)
Assigned to Perfusion Tech APS, Roskilde (DK)
Filed by Perfusion Tech APS, Roskilde (DK)
Filed on Dec. 18, 2020, as Appl. No. 17/127,217.
Application 17/127,217 is a continuation in part of application No. 16/738,078, filed on Jan. 9, 2020, granted, now 10,912,471.
Application 16/738,078 is a continuation of application No. PCT/EP2019/065648, filed on Jun. 14, 2019.
Claims priority of application No. 18177783 (EP), filed on Jun. 14, 2018.
Prior Publication US 2021/0100461 A1, Apr. 8, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/0275 (2006.01); A61B 5/1455 (2006.01); A61B 5/00 (2006.01); A61B 5/026 (2006.01); G01N 21/64 (2006.01)
CPC A61B 5/0275 (2013.01) [A61B 5/0059 (2013.01); A61B 5/0261 (2013.01); A61B 5/14551 (2013.01); G01N 21/6486 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method of automatic blood perfusion assessment of a tissue of an anatomical structure of a subject, the method comprising:
administering a first fluorescence imaging agent having an emission maximum into a vein of the subject as a first bolus and a series of subsequent boluses with a predefined time between the subsequent boluses, the first bolus, and each subsequent bolus, comprising an amount of the first fluorescence imaging agent corresponding to less than 0.005 mg ICG/kg body weight of the subject, wherein the amount of the first fluorescence imaging agent is dissolved in a liquid;
acquiring and analysing a time series of fluorescence images of the tissue of said anatomical structure following administering the first bolus of the first fluorescence imaging agent, producing an analysis based on a fluorescence intensity in said images; and
determining at least one blood perfusion parameter of said anatomical structure based on said analysis.