US 11,910,809 B2
Microbial compositions and methods of use for improving milk production
Mallory Embree, San Diego, CA (US); Luke Picking, San Diego, CA (US); Grant Gogul, Cardiff, CA (US); and Janna Tarasova, San Diego, CA (US)
Assigned to Native Microbials, Inc., San Diego, CA (US)
Filed by Native Microbials, Inc., San Diego, CA (US)
Filed on Feb. 23, 2022, as Appl. No. 17/678,634.
Application 17/678,634 is a division of application No. 17/178,552, filed on Feb. 18, 2021, granted, now 11,291,219.
Application 17/178,552 is a continuation of application No. 16/871,290, filed on May 11, 2020, granted, now 10,966,437, issued on Apr. 6, 2021.
Application 16/871,290 is a continuation of application No. 16/534,481, filed on Aug. 7, 2019, granted, now 10,645,952, issued on May 12, 2020.
Application 16/534,481 is a continuation of application No. 16/029,398, filed on Jul. 6, 2018, granted, now 10,398,154, issued on Sep. 3, 2019.
Application 16/029,398 is a continuation of application No. PCT/US2017/012573, filed on Jan. 6, 2017.
Claims priority of provisional application 62/415,908, filed on Nov. 1, 2016.
Claims priority of provisional application 62/334,816, filed on May 11, 2016.
Claims priority of provisional application 62/276,531, filed on Jan. 8, 2016.
Claims priority of provisional application 62/276,142, filed on Jan. 7, 2016.
Prior Publication US 2022/0287330 A1, Sep. 15, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A23K 10/18 (2016.01); A61K 36/062 (2006.01); A61P 15/04 (2006.01); A61K 35/74 (2015.01); A61K 36/06 (2006.01); A61K 36/064 (2006.01); A23K 40/35 (2016.01); A23K 50/10 (2016.01); A61K 9/00 (2006.01); A61K 35/742 (2015.01); A23L 31/10 (2016.01); A23L 33/135 (2016.01); A61P 31/04 (2006.01); A61K 35/741 (2015.01); A61K 39/02 (2006.01); C12N 1/14 (2006.01); C12N 1/20 (2006.01); A23K 20/158 (2016.01); A23K 20/163 (2016.01); A23K 20/28 (2016.01); A23K 10/30 (2016.01); A23K 10/37 (2016.01); A61K 35/748 (2015.01)
CPC A23K 10/18 (2016.05) [A23K 10/30 (2016.05); A23K 10/37 (2016.05); A23K 20/158 (2016.05); A23K 20/163 (2016.05); A23K 20/28 (2016.05); A23K 40/35 (2016.05); A23K 50/10 (2016.05); A23L 31/10 (2016.08); A23L 33/135 (2016.08); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 35/74 (2013.01); A61K 35/741 (2013.01); A61K 35/742 (2013.01); A61K 36/06 (2013.01); A61K 36/062 (2013.01); A61K 36/064 (2013.01); A61K 39/02 (2013.01); A61P 15/04 (2018.01); A61P 31/04 (2018.01); C12N 1/14 (2013.01); C12N 1/20 (2013.01); A61K 35/748 (2013.01)] 27 Claims
OG exemplary drawing
 
1. An orally deliverable composition for increasing milk production or improving milk compositional characteristics in a ruminant, comprising:
a. a bacterium comprising a 16 S nucleic acid sequence sharing at least 98% sequence identity to SEQ ID NO: 28;
b. a fungus comprising an ITS nucleic acid sequence sharing at least 98% sequence identity to SEQ ID NO: 32;
c. a bacterium comprising a 16 S nucleic acid sequence sharing at least 98% sequence identity to SEQ ID NO: 1; and/or
d. a bacterium comprising a 16 S nucleic acid sequence sharing at least 98% sequence identity to SEQ ID NO: 2067; and
e. a carrier suitable for oral ruminant administration, wherein the composition is formulated to protect the one or more bacteria and/or fungus from external stressors prior to entering the gastrointestinal tract of the ruminant.