US 12,237,161 B2
Identification of sample subspecies based on particle charge behavior under structural change-inducing sample conditions
David E. Clemmer, Bloomington, IN (US); Martin F. Jarrold, Bloomington, IN (US); Tarick J. El-Baba, Bloomington, IN (US); and Corinne A. Lutomski, Bloomington, IN (US)
Assigned to THE TRUSTEES OF INDIANA UNIVERSITY, Bloomington, IN (US)
Filed by THE TRUSTEES OF INDIANA UNIVERSITY, Bloomington, IN (US)
Filed on Feb. 8, 2024, as Appl. No. 18/436,697.
Application 18/436,697 is a continuation of application No. 17/602,000, granted, now 11,942,317, previously published as PCT/US2020/029287, filed on Apr. 22, 2020.
Claims priority of provisional application 62/950,103, filed on Dec. 18, 2019.
Claims priority of provisional application 62/839,080, filed on Apr. 26, 2019.
Claims priority of provisional application 62/837,373, filed on Apr. 23, 2019.
Prior Publication US 2024/0242955 A1, Jul. 18, 2024
Int. Cl. H01J 49/16 (2006.01); H01J 49/00 (2006.01); H01J 49/04 (2006.01); H01J 49/26 (2006.01)
CPC H01J 49/165 (2013.01) [H01J 49/0031 (2013.01); H01J 49/0468 (2013.01); H01J 49/26 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An instrument for analyzing charged particles, comprising:
an ion generator configured to generate charged particles from each of a plurality of samples of particles, each of the plurality of samples of particles having a different chemical composition within a range of chemical compositions over which each of the plurality of samples of particles undergo structural changes,
a mass spectrometer configured to receive the charged particles generated by the ion generator from each of the plurality of samples of particles and to measure masses and charge magnitudes of the generated charged particles generated from each of the plurality of samples having the different chemical compositions within the range of chemical compositions,
a processor, and
a memory having instructions stored therein executable by the processor to cause the processor to (a) control the mass spectrometer to measure at least the charge magnitudes of the generated charged particles generated from each of the plurality of samples having the different chemical compositions, (b) determine an average charge magnitude of the generated charged particles generated from each of the plurality of samples having the different chemical compositions based on the measured charge magnitudes, and (c) determine an average charge magnitude profile over the range of chemical compositions based on the determined average charge magnitudes.