	US 12,236,694 B2
	Systems and methods for processing images to determine image-based computational biomarkers from liquid specimens
Brandon Rothrock, Los Angeles, CA (US); Jillian Sue, New York, NY (US); Matthew Houliston, Boston, MA (US); Patricia Raciti, New York, NY (US); and Leo Grady, Darien, CT (US)
Assigned to Paige.AI, Inc., New York, NY (US)
Filed by PAIGE.AI, Inc., New York, NY (US)
Filed on Jul. 3, 2023, as Appl. No. 18/346,391.
Application 18/346,391 is a continuation of application No. 17/519,847, filed on Nov. 5, 2021, granted, now 11,721,115.
Application 17/519,847 is a continuation of application No. 17/511,871, filed on Oct. 27, 2021, granted, now 11,663,838, issued on May 30, 2023.
Claims priority of provisional application 63/107,389, filed on Oct. 29, 2020.
Prior Publication US 2023/0360414 A1, Nov. 9, 2023
Int. Cl. G06V 20/69 (2022.01); G06F 18/2431 (2023.01); G06N 20/00 (2019.01); G06T 7/00 (2017.01); G06T 7/11 (2017.01); G06T 7/194 (2017.01); G16H 30/40 (2018.01)

CPC G06V 20/695 (2022.01) [G06F 18/2431 (2023.01); G06N 20/00 (2019.01); G06T 7/0012 (2013.01); G06T 7/11 (2017.01); G06T 7/194 (2017.01); G06V 20/698 (2022.01); G16H 30/40 (2018.01); G06T 2207/20081 (2013.01); G06T 2207/30024 (2013.01)]

19 Claims

1. A computer-implemented method for identifying a specimen category, comprising:

receiving one or more digital images of a cytology specimen at a digital storage device;

isolating one or more cell images using the one or more digital images by isolating a set of individual images of cells within the one or more digital images using a segmentation system and/or a detection system;

extracting at least one cell patch from the one or more digital images;

identifying the at least one cell patch as belonging to either cell or background;

extracting one or more cellular features using the cell images; and

determining a specimen category from the one or more cellular features using a trained output aggregation model.