US 12,235,277 B2
Photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes
Mark J. Lim, Reading, MA (US); Gargey Yagnik, Hopkinton, MA (US); and Kenneth J. Rothschild, Newton, MA (US)
Assigned to AmberGen, Inc., Billerica, MA (US)
Filed by AmberGen, Inc., Billerica, MA (US)
Filed on Feb. 28, 2024, as Appl. No. 18/590,471.
Application 18/590,471 is a continuation of application No. 17/862,990, filed on Jul. 12, 2022, granted, now 11,940,447.
Application 17/862,990 is a continuation of application No. 17/399,417, filed on Aug. 11, 2021.
Claims priority of provisional application 63/106,990, filed on Oct. 29, 2020.
Prior Publication US 2024/0264167 A1, Aug. 8, 2024
Int. Cl. G01N 33/68 (2006.01); C07C 271/20 (2006.01); C12Q 1/6841 (2018.01)
CPC G01N 33/6851 (2013.01) [C07C 271/20 (2013.01); C12Q 1/6841 (2013.01); G01N 2400/00 (2013.01); G01N 2458/15 (2013.01)] 2 Claims
OG exemplary drawing
 
1. A composition comprising the general chemical structure:

OG Complex Work Unit Chemistry
wherein A is a first linker unit comprising at least 1 amine, X is a protecting group covalently bonded to the nitrogen atom of said amine, wherein said protecting group is selected from Fmoc and Boc, and B is a second linker unit.