US 12,235,233 B2
Current measurement apparatus, molecular entity sensing apparatus, method of measuring a current, method of sensing a molecular entity
David A. Fish, AE Eindhoven (NL); Hugo Veenstra, AE Eindhoven (NL); and Emil Totey, AE Eindhoven (NL)
Assigned to Oxford Nanopore Technologies PLC, Oxford (GB)
Filed by Oxford Nanopore Technologies PLC, Oxford (GB)
Filed on Apr. 23, 2024, as Appl. No. 18/643,194.
Application 18/643,194 is a continuation of application No. 17/440,222, granted, now 11,994,486, previously published as PCT/GB2020/050248, filed on Feb. 4, 2020.
Claims priority of application No. 1903742.3 (GB), filed on Mar. 19, 2019.
Prior Publication US 2024/0393282 A1, Nov. 28, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/12 (2006.01); G01N 33/487 (2006.01)
CPC G01N 27/128 (2013.01) [G01N 33/48721 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A method of measuring current, comprising:
using a first charge amplifier to integrate a current to be measured;
filtering an output from the first charge amplifier using a first low pass filter module and a second low pass filter module; and
using a second charge amplifier to integrate a current derived from the filtered output from the first charge amplifier, wherein:
the first charge amplifier is reset at the start of each of a plurality of sensing frames;
at least a first sample of the output from the first charge amplifier is obtained in each sensing frame; and
the sampling of the first sample alternates from one sensing frame to the next sensing frame between sampling via the first low pass filter module and sampling via the second low pass filter module.