	US 12,234,519 B2
	Kit, device, and method for detecting bladder cancer
Makiko Yoshimoto, Kamakura (JP); Hiroko Sudo, Kamakura (JP); Satoko Kozono, Kamakura (JP); Junpei Kawauchi, Kamakura (JP); Takahiro Ochiya, Tokyo (JP); Hiroyuki Fujimoto, Tokyo (JP); Wataru Usuba, Tokyo (JP); and Juntaro Matsuzaki, Tokyo (JP)
Assigned to TORAY INDUSTRIES, INC., Tokyo (JP); and NATIONAL CANCER CENTER, Tokyo (JP)
Filed by TORAY INDUSTRIES, INC., Tokyo (JP); and NATIONAL CANCER CENTER, Tokyo (JP)
Filed on Jun. 22, 2023, as Appl. No. 18/339,400.
Application 18/339,400 is a division of application No. 17/050,134, granted, now 11,732,307, previously published as PCT/JP2019/017536, filed on Apr. 25, 2019.
Claims priority of application No. 2018-084416 (JP), filed on Apr. 25, 2018.
Prior Publication US 2024/0060142 A1, Feb. 22, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/6886 (2018.01)

CPC C12Q 1/6886 (2013.01) [C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)]

9 Claims

1. A method for detecting bladder cancer, comprising:

measuring an expression level of miR-4652-5p in a sample from a human subject;

determining that the level of miR-4652-5p in the sample from the human subject is increased in comparison to a level of miR-4652-5p in a control sample from a human subject without bladder cancer;

determining that the human subject has bladder cancer based on the increased expression level of miR-4652-5p; and

treating the human subject for the bladder cancer;

wherein the sample is blood, serum, or plasma; and

wherein the treating comprises surgery, radiotherapy, chemotherapy, or a combination thereof.