US 12,234,489 B2
Compositions for treating ectopic calcification disorders, and methods using same
Demetrios Braddock, New Haven, CT (US); and Enrique De La Cruz, New Haven, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Filed by YALE UNIVERSITY, New Haven, CT (US)
Filed on Dec. 19, 2022, as Appl. No. 18/068,256.
Application 18/068,256 is a continuation of application No. 17/075,398, filed on Oct. 20, 2020, abandoned.
Application 17/075,398 is a continuation of application No. 15/777,446, abandoned, previously published as PCT/US2016/063034, filed on Nov. 21, 2016.
Claims priority of provisional application 62/257,883, filed on Nov. 20, 2015.
Prior Publication US 2023/0227800 A1, Jul. 20, 2023
Int. Cl. C12N 9/16 (2006.01); A61K 38/00 (2006.01); A61K 38/38 (2006.01); A61K 38/46 (2006.01); A61K 39/395 (2006.01); C07K 14/76 (2006.01); C12N 9/14 (2006.01)
CPC C12N 9/16 (2013.01) [A61K 38/385 (2013.01); A61K 38/465 (2013.01); A61K 39/395 (2013.01); C07K 14/76 (2013.01); C12N 9/14 (2013.01); C12Y 301/03036 (2013.01); C12Y 301/04001 (2013.01); C12Y 301/04012 (2013.01); C12Y 306/01009 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/30 (2013.01); C07K 2319/31 (2013.01)] 13 Claims
 
1. A method of treating pathological calcification of soft tissue in a subject in need thereof,
the method comprising administering to the subject a therapeutically effective amount of a polypeptide comprising a soluble ecto-nucleotide pyrophosphate/phosphodiesterase-3 (ENPP3) polypeptide, whereby pathological calcification in the subject is treated.