US 12,234,291 B2
IL2RB binding molecules and methods of use
Robert Kastelein, Menlo Park, CA (US); Deepti Rokkam, Menlo Park, CA (US); Patrick J. Lupardus, Menlo Park, CA (US); and Sandro Vivona, Menlo Park, CA (US)
Assigned to Synthekine, Inc., Menlo Park, CA (US)
Appl. No. 18/006,528
Filed by Synthekine, Inc., Menlo Park, CA (US); and Sandro Vivona, Menlo Park, CA (US)
PCT Filed Aug. 5, 2021, PCT No. PCT/US2021/044803
§ 371(c)(1), (2) Date Jan. 23, 2023,
PCT Pub. No. WO2022/032006, PCT Pub. Date Feb. 10, 2022.
Claims priority of provisional application 63/135,884, filed on Jan. 11, 2021.
Claims priority of provisional application 63/136,095, filed on Jan. 11, 2021.
Claims priority of provisional application 63/078,745, filed on Sep. 15, 2020.
Claims priority of provisional application 63/061,562, filed on Aug. 5, 2020.
Prior Publication US 2023/0272090 A1, Aug. 31, 2023
Int. Cl. C07K 16/28 (2006.01)
CPC C07K 16/2866 (2013.01) [C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/92 (2013.01)] 37 Claims
 
1. A IL2Rb binding molecule that specifically binds to the extracellular domain of IL2Rb, wherein the IL2Rb binding molecule comprises a single domain antibody (sdAb), and wherein the sdAb comprises a complementary determining region 1 (CDR1), a CDR2, and a CDR3 as shown in a row of the table below:
 
CDR1 CDR2 CDR3
 
YTYDTSDMS DIDSGDWAAYADAVKG SYWKWGKLNNF
(SEQ ID  (SEQ ID NO: 3) (SEQ ID NO: 4)
NO: 2)
 
 
 
FTFSNYWIF TSNTGGDTTKYADSVKG GRCARSG
(SEQ ID  (SEQ ID NO: 7) (SEQ ID NO: 8)
NO: 6)
 
 
 
FRFSNYGMS YINGDGSRTHYADSVKG GLSRDGWSLSAAS
(SEQ ID  (SEQ ID NO: 11) (SEQ ID NO: 12)
NO: 10)
 
 
 
YTTYSFNYMG VIYTGGGSTLYADSVKG DDQRFASPLYAYFGY
(SEQ ID  (SEQ ID NO: 15) (SEQ ID NO: 16)
NO: 14)
 
 
 
DTKSIRCMG AIDREGFATYADSVYD QNMCRVVRGAMTGVDY
(SEQ ID  (SEQ ID NO: 19) (SEQ ID NO: 20)
NO: 18)
 
 
 
YTASRYCMA AIHPGGGTTYYADSVKG GSLWVPFGDRCAANY
(SEQ ID  (SEQ ID NO: 23) (SEQ ID NO: 24)
NO: 22)
 
 
 
YEYCRIHMT SIGSDGRKTYANSVTG EYLYGLGCPDGSAY
(SEQ ID  (SEQ ID NO: 27) (SEQ ID NO: 28)
NO: 26)
 
 
 
YTYSSYYCMG AIDSDGSTSYADSVKG SYEVVDCYPSGYGQDY
(SEQ ID  (SEQ ID NO: 31) (SEQ ID NO: 32)
NO: 30)