1. A method of inhibiting the transition of tubular epithelial cells (TECs) to a mesenchymal cell-like phenotype in a subject, comprising administering to a subject in need thereof an effective amount of: an anti-interleukin 11 (IL-11) antibody or an antigen-binding fragment thereof which is an antagonist of IL-11-mediated signaling, thereby inhibiting the transition of TECs to a mesenchymal cell-like phenotype in the subject, wherein the subject in need thereof has proximal and/or distal TEC damage.