US 12,234,242 B2
Radiopharmaceuticals, radioimaging agents, and uses thereof
Nicholas Alan Zia, Melbourne (AU); and Paul Stephen Donnelly, Melbourne (AU)
Assigned to Clarity Pharmaceuticals Ltd, Eveleigh (AU)
Filed by Clarity Pharmaceuticals Ltd, Eveleigh (AU)
Filed on Aug. 11, 2023, as Appl. No. 18/233,135.
Application 18/233,135 is a continuation of application No. 17/834,773, filed on Jun. 7, 2022, granted, now 11,970,503.
Application 17/834,773 is a continuation of application No. 17/198,131, filed on Mar. 10, 2021, granted, now 11,384,088, issued on Jul. 12, 2022.
Application 17/198,131 is a continuation of application No. 16/619,073, granted, now 10,975,089, issued on Apr. 13, 2021, previously published as PCT/AU2018/050555, filed on Jun. 5, 2018.
Claims priority of application No. 2017902151 (AU), filed on Jun. 6, 2017.
Prior Publication US 2023/0382918 A1, Nov. 30, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 487/08 (2006.01); A61K 9/00 (2006.01); A61K 33/34 (2006.01); A61K 51/04 (2006.01); A61K 51/06 (2006.01); C07F 1/08 (2006.01); C07F 1/00 (2006.01)
CPC C07D 487/08 (2013.01) [A61K 9/0019 (2013.01); A61K 33/34 (2013.01); A61K 51/0497 (2013.01); A61K 51/06 (2013.01); C07F 1/08 (2013.01); C07F 1/00 (2013.01)] 20 Claims
 
1. A method for the treatment of a cancer, the method comprising administering to a subject in need thereof a compound of Formula (I), or a salt, complex, or solvate thereof:

OG Complex Work Unit Chemistry
wherein:
X is a group selected from H, OH, halogen, cyano, NO2, NH2, optionally substituted C1-C12 alkyl, optionally substituted amino, optionally substituted amide and optionally substituted aryl;
Y is an optionally substituted C1-C12 alkylene group, wherein one or more of the methylene groups in the alkylene group may be further optionally substituted for a group selected from amide, carbonyl, urea and thiourea;
m is 0, 1, or 2; and
n is 0, 1, or 2;
wherein the compound of Formula (I) is complexed with a radionuclide of a metal selected from the group consisting of Cu, Tc, Ga, Co, In, Fe and Ti.