US 12,233,414 B1
Non-healthcare setting biological testing system
Dereck Tatman, San Diego, CA (US); and Ron Mccullough, Encinitas, CA (US)
Assigned to Intrigue Health, Inc., San Diego, CA (US)
Appl. No. 18/288,967
Filed by Intrigue Health, Inc., San Diego, CA (US)
PCT Filed Jul. 14, 2023, PCT No. PCT/US2023/027824
§ 371(c)(1), (2) Date Oct. 30, 2023,
PCT Pub. No. WO2024/025750, PCT Pub. Date Feb. 1, 2024.
Claims priority of provisional application 63/393,203, filed on Jul. 28, 2022.
Int. Cl. B01L 3/00 (2006.01)
CPC B01L 3/502715 (2013.01) [B01L 3/502738 (2013.01); B01L 3/50825 (2013.01); B01L 2200/027 (2013.01); B01L 2200/04 (2013.01); B01L 2200/0647 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/023 (2013.01); B01L 2300/042 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/0681 (2013.01); B01L 2400/0478 (2013.01); B01L 2400/0605 (2013.01)] 36 Claims
OG exemplary drawing
 
1. A kit for diagnosing a biological sample from a user, the kit comprising:
a collection container comprising:
a collection tube with a tube bottom; and
a cap comprising a cap outlet;
wherein when the cap is arranged on the collection tube such that the collection tube and cap define a tube volume that holds the biological sample;
and wherein the tube bottom is constructed to slide within the collection tube, thereby changing the tube volume;
a cartridge comprising:
a container port constructed to removably dock with the collection container;
a reaction chamber with a first optical window that allows light to pass there through, the reaction chamber comprising one or more assays that each interacts with a target (1) interact with a target in the biological sample when the target is present, and (2) change a spectral characteristic of light directed into the reaction chamber when there is an interaction; and
a microfluidic channel fluidly connecting the container port to the reaction chamber;
a reader comprising:
a cartridge slot;
a light source;
a door with a sample injection piston;
a light detector;
a transmitter;
an unlocked configuration, wherein the cartridge may be installed into or uninstalled from the cartridge slot;
a fixed/aligned configuration, wherein the cartridge with a docked collection container is arranged into the cartridge slot, and the door is closed such that:
the cartridge is fixed relative to the reader and the light source;
light detector align in a fixed position with the first optical window; and
the sample injection piston aligns with the tube bottom;
a processor connected to the light source, the sample injection piston, the light detector, and the transmitter, the processor configured to perform the following steps in the fixed/aligned configuration:
actuate the sample injection piston to push the tube bottom, reducing the tube volume, thereby forcing the biological sample from the collection container, through the cap outlet, the container port, the microfluidic channel and to the reaction chamber;
actuate the light source;
receive data from the light detector; and
transmit to an external processor via the transmitter a result based on the data.