US 12,233,265 B2
Systems and methods for treating cardiac dysfunction through peripheral nerve stimulation
Samuel Richard Hamner, San Francisco, CA (US); Kathryn H. Rosenbluth, San Francisco, CA (US); Serena HanYing Wong, Palo Alto, CA (US); and Erika Kristine Ross, San Mateo, CA (US)
Assigned to Cala Health, Inc., San Mateo, CA (US)
Appl. No. 16/327,780
Filed by Cala Health, Inc., San Mateo, CA (US)
PCT Filed Aug. 24, 2017, PCT No. PCT/US2017/048424
§ 371(c)(1), (2) Date Feb. 22, 2019,
PCT Pub. No. WO2018/039458, PCT Pub. Date Mar. 1, 2018.
Claims priority of provisional application 62/423,169, filed on Nov. 16, 2016.
Claims priority of provisional application 62/379,253, filed on Aug. 25, 2016.
Prior Publication US 2021/0283400 A1, Sep. 16, 2021
Int. Cl. A61N 1/36 (2006.01); A61N 1/04 (2006.01); A61N 1/39 (2006.01)
CPC A61N 1/36117 (2013.01) [A61N 1/0456 (2013.01); A61N 1/0484 (2013.01); A61N 1/36178 (2013.01); A61N 1/395 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A transcutaneous method for treating at least one of cardiac arrhythmias and hypertension with selective activation, comprising:
positioning a first peripheral nerve effector on a patient's skin on an extremity of the patient;
positioning a second peripheral nerve effector on the patient's skin on the extremity of the patient;
delivering a first electrical nerve stimulation signal transcutaneously to the first peripheral nerve effector to stimulate a first peripheral nerve relating to the cardiac arrhythmia or hypertension; and
delivering a second electrical nerve stimulation signal transcutaneously to the second peripheral nerve effector to stimulate a second peripheral nerve relating to the cardiac arrhythmia or hypertension,
wherein the first and the second peripheral nerves are selected from the group consisting of one or more of: a median nerve, a radial nerve, and an ulnar nerve,
wherein the first electrical nerve stimulation signal activates an A-alpha fiber and a C-fiber of the first peripheral nerve,
wherein the second electrical nerve stimulation signal activates an A-alpha fiber and one or more of: A-delta or C-fibers of the second peripheral nerve,
wherein the second peripheral nerve is different from the first peripheral nerve, and
wherein the method does not utilize any implantable components, and only involves transcutaneous stimulation.