1. A method of creating serrations at a treatment site in a vessel, comprising: providing a serration balloon comprising a strip including a plurality of wedge dissectors spaced apart along a surface of the strip, the strip extending longitudinally along an outer surface of the serration balloon, each wedge dissector comprising a radially outward facing surface and lateral surfaces; expanding the serration balloon at the site such that the radially outward facing surface of the plurality of wedge dissectors directly contact tissue of the intima layer of the vessel wall creating nucleation sites for a cleavage; and continuing to expand the serration balloon such that radially outward facing surface of the plurality of wedge dissectors no longer contact tissue, but the lateral surfaces of the wedge dissector contact tissue to expand the cleavage plane along the entire length of the strip.