US 12,233,189 B2
Smart artificial lung and perfusion systems
Joseph Potkay, Plymouth, MI (US); Robert H. Bartlett, Ann Arbor, MI (US); and Alvaro Rojas-Pena, Ann Arbor, MI (US)
Assigned to The Regents of The University of Michigan, Ann Arbor, MI (US); and United States Government As Represented by the Department of Veterans Affairs, Washington, DC (US)
Appl. No. 17/054,909
Filed by THE REGENTS OF THE UNIVERSITY OF MICHIGAN, Ann Arbor, MI (US)
PCT Filed Jun. 18, 2019, PCT No. PCT/US2019/037675
§ 371(c)(1), (2) Date Nov. 12, 2020,
PCT Pub. No. WO2019/246057, PCT Pub. Date Dec. 26, 2019.
Claims priority of provisional application 62/687,456, filed on Jun. 20, 2018.
Prior Publication US 2021/0228792 A1, Jul. 29, 2021
Int. Cl. A61M 1/16 (2006.01); A61M 1/36 (2006.01)
CPC A61M 1/1698 (2013.01) [A61M 1/1603 (2014.02); A61M 1/3638 (2014.02); A61M 2205/3327 (2013.01); A61M 2205/3334 (2013.01); A61M 2230/202 (2013.01); A61M 2230/205 (2013.01)] 8 Claims
OG exemplary drawing
 
1. An artificial lung system for a patient, the system comprising:
a membrane lung system having an gas inlet, a blood inlet, a blood outlet, and an exhaust;
a gas system operably coupled to the gas inlet of the membrane lung system for introducing gas to the membrane lung system;
a gas phase CO2 sensor disposed downstream of the exhaust of the membrane lung system and monitoring an exhaust gas CO2 (EGCO2) level, the gas phase CO2 sensor outputting a CO2 signal in response to a detected EGCO2 level; and
a feedback controller receiving the CO2 signal and outputting an gas system control signal to the gas system responsive thereto such that if EGCO2 content increases relative to a target CO2 level, the feedback controller increases sweep flow of the gas system to remove more CO2 from the blood flowing through the blood inlet to the blood outlet, if EGCO2 content decreases relative to the target CO2 level, the feedback controller automatically decreases sweep flow of the gas system to reduce CO2 removal.