	US 12,233,168 B2
	Localization of payload delivery systems to tumor sites via beacon cell targeting
Neil S. Forbes, Hadley, MA (US); Nele Van Dessel, Easthampton, MA (US); John Klier, Leverett, MA (US); Shane Taylor, Amherst, MA (US); and Vishnu Raman, Amherst, MA (US)
Assigned to University of Massachusetts, Boston, MA (US)
Appl. No. 17/594,193
Filed by University of Massachusetts, Boston, MA (US)
PCT Filed Apr. 8, 2020, PCT No. PCT/US2020/027302 § 371(c)(1), (2) Date Oct. 6, 2021, PCT Pub. No. WO2020/210378, PCT Pub. Date Oct. 15, 2020.
Claims priority of provisional application 62/831,122, filed on Apr. 8, 2019.
Prior Publication US 2022/0151947 A1, May 19, 2022
Int. Cl. A61K 9/51 (2006.01); A61K 47/68 (2017.01); A61K 47/69 (2017.01); B82Y 5/00 (2011.01)

CPC A61K 9/5169 (2013.01) [A61K 47/6835 (2017.08); A61K 47/6935 (2017.08); B82Y 5/00 (2013.01)]

17 Claims

1. A method to target tumor-associated bacterial beacon cells in tumors of a subject comprising:

i) first administering to the subject Salmonella bacterial beacon cells that colonize tumors, and

ii) second administering to the subject nanoparticles having a payload and a functionable group that targets the colonized beacon cells of i).