US 12,233,155 B2
Polynucleotides encoding antibodies which bind the EC3 domain of cadherin-6 (CDH6) and possess internalization ability
Atsuko Saito, Tokyo (JP); Tsuyoshi Hirata, Tokyo (JP); and Kensuke Nakamura, Tokyo (JP)
Assigned to DAIICHI SANKYO COMPANY, LIMITED, Tokyo (JP)
Filed by DAIICHI SANKYO COMPANY, LIMITED, Tokyo (JP)
Filed on Jul. 26, 2022, as Appl. No. 17/874,239.
Application 17/874,239 is a division of application No. 16/613,203, granted, now 11,446,386, previously published as PCT/JP2018/018572, filed on May 14, 2018.
Claims priority of application No. 2017-096749 (JP), filed on May 15, 2017.
Prior Publication US 2023/0226205 A1, Jul. 20, 2023
Int. Cl. A61K 47/68 (2017.01); A61K 9/00 (2006.01); A61K 31/4745 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01)
CPC A61K 9/0019 (2013.01) [A61K 31/4745 (2013.01); A61K 47/68033 (2023.08); A61K 47/68037 (2023.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); C07K 16/28 (2013.01); C07K 2317/24 (2013.01); C07K 2317/40 (2013.01); C07K 2317/41 (2013.01); C07K 2317/565 (2013.01); C07K 2317/732 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01)] 10 Claims
 
1. A polynucleotide encoding an antibody or a functional fragment of the antibody that specifically binds to the amino acid sequence of the EC3 domain of cadherin-6 shown in SEQ ID NO: 4 and possesses internalization ability that permits cellular uptake.