US 12,233,140 B2
Hyperbranched polyglycerol-coated particles and methods of making and using thereof
Yang Deng, Edison, NJ (US); Asiri Ediriwickrema, Cary, NC (US); and W. Mark Saltzman, New Haven, CT (US)
Assigned to YALE UNIVERSITY, New Haven, CT (US)
Filed by Yale University, New Haven, CT (US)
Filed on Nov. 20, 2023, as Appl. No. 18/514,738.
Application 16/882,000 is a division of application No. 15/269,456, filed on Sep. 19, 2016, granted, now 10,660,828, issued on May 26, 2020.
Application 18/514,738 is a continuation of application No. 16/882,000, filed on May 22, 2020, granted, now 11,826,438.
Application 15/269,456 is a continuation in part of application No. PCT/US2015/030169, filed on May 11, 2015.
Claims priority of provisional application 61/991,025, filed on May 9, 2014.
Prior Publication US 2024/0173216 A1, May 30, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/02 (2006.01); A61K 8/90 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 9/50 (2006.01); A61K 9/51 (2006.01); A61K 31/4178 (2006.01); A61K 31/427 (2006.01); A61K 31/4745 (2006.01); A61K 39/00 (2006.01); A61K 47/34 (2017.01); A61Q 17/04 (2006.01); C07C 59/06 (2006.01); C07C 59/08 (2006.01); C08G 83/00 (2006.01)
CPC A61K 8/0241 (2013.01) [A61K 8/90 (2013.01); A61K 9/0014 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 9/1647 (2013.01); A61K 9/5031 (2013.01); A61K 9/5146 (2013.01); A61K 9/5153 (2013.01); A61K 31/4178 (2013.01); A61K 31/427 (2013.01); A61K 31/4745 (2013.01); A61K 47/34 (2013.01); A61Q 17/04 (2013.01); C07C 59/06 (2013.01); C07C 59/08 (2013.01); C08G 83/005 (2013.01); A61K 39/00 (2013.01); A61K 2800/412 (2013.01); A61K 2800/413 (2013.01); A61K 2800/624 (2013.01)] 19 Claims
 
1. Particles comprising:
(a) a core comprising one or more polymers;
(b) a shell comprising hyperbranched polyglycerol; and
(c) one or more nucleic acids, one or more peptides, or a combination thereof;
wherein the one or more polymers are more hydrophobic than the hyperbranched polyglycerol;
wherein the hyperbranched polyglycerol is covalently bound to the one or more polymers;
wherein the hyperbranched polyglycerol at the surface of the particles comprises hydroxyl groups converted to one or more reactive functional groups selected from the group consisting of aldehydes, amines, oximes, and O-substituted oximes; and
optionally wherein the particles are modified by attachment of polyethylene glycol to the surface of the particles.