	US 12,233,131 B2
	Cationic calibrated-size gas-filled microvesicles
Anne Lassus, Carouge (CH); and Samir Cherkaoui, Feigeres (FR)
Assigned to Bracco Suisse SA, Cadempino (CH)
Appl. No. 18/565,586
Filed by Bracco Suisse SA, Cadempino (CH)
PCT Filed Jul. 14, 2022, PCT No. PCT/EP2022/069809 § 371(c)(1), (2) Date Nov. 30, 2023, PCT Pub. No. WO2023/285628, PCT Pub. Date Jan. 19, 2023.
Claims priority of application No. 21185579 (EP), filed on Jul. 14, 2021.
Prior Publication US 2024/0277866 A1, Aug. 22, 2024
Int. Cl. A61K 47/69 (2017.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01); A61K 48/00 (2006.01)

CPC A61K 47/6925 (2017.08) [A61K 47/10 (2013.01); A61K 47/24 (2013.01); A61K 48/0041 (2013.01)]

18 Claims

1. A suspension of calibrated gas-filled microvesicles with a stabilizing envelope comprising an amphiphilic material, wherein:

said amphiphilic material comprises a cationic lipid and a neutral or cationic amphiphilic polymeric compound, said amphiphilic polymeric compound comprising a respective hydrophilic and a hydrophobic portion and being present in a molar amount higher than 3%; and

said gas-filled microvesicles have a geometric standard deviation (GSD) value of at least 1.25 or lower.