US 12,233,111 B2
Compositions comprising pharmaceutically acceptable salts of glucagon-like peptide-1 analogs and uses thereof
Tyler Brown, Cambridge, MA (US); and Kelly Ibsen, Boston, MA (US)
Assigned to I2O THERAPEUTICS, INC., Cambridge, MA (US)
Filed by i2O Therapeutics, Inc., Cambridge, MA (US)
Filed on Feb. 16, 2024, as Appl. No. 18/444,463.
Application 18/444,463 is a continuation of application No. PCT/US2022/049585, filed on Nov. 10, 2022.
Claims priority of provisional application 63/380,125, filed on Oct. 19, 2022.
Claims priority of provisional application 63/334,410, filed on Apr. 25, 2022.
Claims priority of provisional application 63/295,197, filed on Dec. 30, 2021.
Claims priority of provisional application 63/277,878, filed on Nov. 10, 2021.
Prior Publication US 2024/0277814 A1, Aug. 22, 2024
Int. Cl. A61K 38/26 (2006.01); A61K 9/08 (2006.01); A61K 31/14 (2006.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/54 (2017.01); A61K 47/68 (2017.01); C07K 14/575 (2006.01); C07K 14/605 (2006.01); C07K 16/24 (2006.01); A61K 38/00 (2006.01)
CPC A61K 38/26 (2013.01) [A61K 9/08 (2013.01); A61K 31/14 (2013.01); A61K 47/12 (2013.01); A61K 47/18 (2013.01); A61K 47/183 (2013.01); A61K 47/186 (2013.01); A61K 47/542 (2017.08); A61K 47/6845 (2017.08); C07K 14/575 (2013.01); C07K 14/605 (2013.01); C07K 16/241 (2013.01); A61K 38/00 (2013.01); C07K 2317/24 (2013.01)] 28 Claims
 
1. A compound having the structure of Formula Ia:

OG Complex Work Unit Chemistry
wherein

OG Complex Work Unit Chemistry
 is a therapeutic agent,
wherein the therapeutic agent has the sequence of SEQ ID NO: 35, and
wherein the compound has a

OG Complex Work Unit Chemistry
molar ratio of from about 1:1 to about 1:7.