	US 12,233,072 B2
	Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds for treating Adenoid Cystic Carcinoma
David Sidransky, Pikesville, MD (US)
Assigned to Immunome, Inc., Bothell, WA (US)
Filed by Immunome, Inc., Bothell, WA (US)
Filed on Sep. 27, 2019, as Appl. No. 16/586,890.
Application 16/586,890 is a continuation in part of application No. PCT/US2019/032239, filed on May 14, 2019.
Claims priority of provisional application 62/827,892, filed on Apr. 2, 2019.
Claims priority of provisional application 62/804,781, filed on Feb. 13, 2019.
Claims priority of provisional application 62/671,748, filed on May 15, 2018.
Prior Publication US 2020/0022990 A1, Jan. 23, 2020
Int. Cl. A61K 31/5513 (2006.01); A61P 35/04 (2006.01)

CPC A61K 31/5513 (2013.01) [A61P 35/04 (2018.01)]

13 Claims

1. A method of suppressing Adenoid Cystic Carcinoma (ACC) tumor growth in a subject or causing regression of an ACC tumor in a subject, wherein said tumor comprises a Notch-activating genetic alteration comprising the step of administering to said subject a composition comprising one or more compounds selected from the group consisting of:

and

or salts thereof.