at least one cannabinoid present in the composition at a concentration of between about 1% (w/w) to about 15% (w/w);

a combination of permeation enhancers each present in the composition at a concentration of between about 9% (w/w) to about 43% (w/w) wherein the combination of permeation enhancers comprises lactic acid (LA), polyethylene glycol-400 (PEG-400), N-methyl-2 pyrrolidone (NMP), and dimethyl sulfoxide (DMSO); and

at least one hydrophilic polymer present in the composition at a concentration of between about 1% (w/w) to about 5% (w/w) wherein the at least one hydrophilic polymer is selected from the group consisting of hydroxyethyl cellulose (HEC), methylcellulose (MC), ethylcellulose (EC), hydroxypropyl cellulose (HPC), hydroxyethyl methylcellulose (HEMC), hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (NaCMC), and combinations thereof;