US 12,233,028 B2
Piston valving for serially connectable drug modules of a combinatorial drug delivery device
Martin John McLoughlin, Hillsborough, NJ (US); Stephen Lawrence Zieminski, East Brunswick, NJ (US); Mark Steven Howansky, Green Brook, NJ (US); Mariano Mumpower, Baltimore, MD (US); Melanie Marie Springer, Baltimore, MD (US); Katherine Alina Goetz, Baltimore, MD (US); and Benjamin Richard Lane, Hydes, MD (US)
Assigned to BRISTOL-MYERS SQUIBB COMPANY, Princeton, NJ (US)
Appl. No. 17/771,198
Filed by Bristol-Myers Squibb Company, Princeton, NJ (US)
PCT Filed Nov. 9, 2020, PCT No. PCT/US2020/059606
§ 371(c)(1), (2) Date Apr. 22, 2022,
PCT Pub. No. WO2021/092534, PCT Pub. Date May 14, 2021.
Claims priority of provisional application 62/933,045, filed on Nov. 8, 2019.
Prior Publication US 2022/0362105 A1, Nov. 17, 2022
Int. Cl. A61J 1/20 (2006.01)
CPC A61J 1/20 (2013.01) [A61J 1/2089 (2013.01); A61J 1/2075 (2015.05)] 7 Claims
OG exemplary drawing
 
1. A module for use in a combinatorial drug delivery device, the module formed to accommodate a drug vial with a septum, the module comprising:
a vial spike formed to pierce the septum of the drug vial with a free end of the vial spike being located interiorly of the septum, the vial spike including an inlet path open at the free end and extending along the vial spike to an inlet opening, and an outlet path open at the free end and extending along the vial spike to an outlet chamber, the outlet path being separate from the inlet path;
a sealing port selectively sealing the inlet opening;
a vent in communication with the inlet path between the inlet opening and the free end;
a slidable piston valve located in the outlet chamber, the piston valve forming a seal in the outlet chamber to define first and second chamber portions, the outlet path being in communication with the first chamber portion;
an outlet fitting in communication with the second chamber portion; and,
a bypass passageway extending between the outlet fitting and an opening in the outlet chamber,
wherein, in an initial state, the piston valve is located in a first position where the first chamber portion is sealed from the bypass passageway, and,
wherein, with negative pressure introduced through the outlet fitting, the piston valve is caused to move to a second position where the first chamber portion is in communication with the bypass passageway.