a) a handle that includes

b) an internal lead screw assembly within the track, the internal lead screw assembly being movable along a major axis of the conduit and including a threaded portion that extends through the track;

c) a lead screw nut that extends about the handle body and threadably engaged with the threaded portion of the internal lead screw assembly, whereby rotation of the lead screw nut while abutting the distal grip causes movement of the internal lead screw assembly relative to the handle;

d) a support member fixed to the handle body,

e) a sheath extending about a portion of the support member and fixed to the internal lead screw assembly, whereby relative movement of the handle body and the lead screw assembly causes relative movement of the support member and the sheath, wherein the support member includes a hypo-tube and a support tube within the hypo-tube, wherein the hypo-tube is fixed to the handle body, and wherein the internal lead screw assembly defines an opening essentially coaxial with the handle, wherein the support member extends through the internal lead screw assembly; and

f) a sheath valve about the support member and disposed within the a slider, the sheath valve having an expanded configuration and a collapsed configuration, wherein a blood tight seal is formed when the sheath valve is in the collapsed configuration;

g) a hemostasis valve about the support member and between the sheath and the internal lead screw assembly, the hemostasis valve including a valve housing and a gasket having a proximal end and a distal end with a collapsible intermediate portion therebetween,