US 12,232,883 B2
Method of modulating epileptogenicity in a patient's brain
Viktor Jirsa, Marseilles (FR); Christophe Bernard, Marseilles (FR); Fabrice Bartolomei, Roquevaire (FR); and Maxime Guye, Saint Cyr sur Mer (FR)
Assigned to UNIVERSITE D'AIX MARSEILLE (AMU), Marseilles (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Marseilles (FR); ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM), Marseilles (FR); and INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR)
Filed by UNIVERSITE D'AIX MARSEILLE (AMU), Marseilles (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris (FR); ASSISTANCE PUBLIQUE—HOPITAUX DE MARSEILLE (AP-HM), Marseilles (FR); and INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR)
Filed on Oct. 25, 2021, as Appl. No. 17/510,182.
Application 17/510,182 is a division of application No. 16/316,803, granted, now 11,191,476, previously published as PCT/IB2016/001164, filed on Jul. 18, 2016.
Prior Publication US 2022/0039736 A1, Feb. 10, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 5/291 (2021.01); A61B 5/369 (2021.01); A61B 34/10 (2016.01); G16H 10/60 (2018.01); G16H 50/50 (2018.01)
CPC A61B 5/4094 (2013.01) [A61B 5/291 (2021.01); A61B 5/369 (2021.01); A61B 34/10 (2016.02); G16H 50/50 (2018.01); A61B 2034/101 (2016.02); A61B 2034/105 (2016.02); G16H 10/60 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A method of modulating epileptogenicity in a brain of an epileptic primate patient comprising the steps of:
providing a virtual primate brain, the virtual primate brain being a computerized platform modelling various zones or nodes of a primate brain and connectivity between the zones or nodes;
providing a model of an epileptogenic zone and of a propagation zone and loading the model in the virtual primate brain to create a virtual epileptic primate brain;
acquiring structural data of the brain of the epileptic primate patient;
reconstructing the epileptic patient brain in the virtual epileptic primate brain using the structural data;
acquiring functional data of the brain of the epileptic primate patient;
fitting the virtual epileptic primate brain against the functional data acquired from the brain of the epileptic primate patient; and
simulating, within the virtual epileptic primate brain, an effect of a network modulation mimicking a clinical intervention of the brain of the epileptic primate patient.