US 12,232,858 B2
T1e-sensitive inversion-recovery imaging for EPROI
Howard J. Halpern, Chicago, IL (US); and Boris Epel, Chicago, IL (US)
Filed by Howard J. Halpern, Chicago, IL (US); and Boris Epel, Chicago, IL (US)
Filed on Mar. 28, 2023, as Appl. No. 18/127,538.
Application 18/127,538 is a division of application No. 15/213,768, filed on Jul. 19, 2016, granted, now 11,612,336.
Application 15/213,768 is a division of application No. 13/032,637, filed on Feb. 22, 2011, granted, now 9,392,957, issued on Jul. 19, 2016.
Claims priority of provisional application 61/445,037, filed on Feb. 21, 2011.
Claims priority of provisional application 61/356,555, filed on Jun. 18, 2010.
Claims priority of provisional application 61/306,917, filed on Feb. 22, 2010.
Prior Publication US 2023/0240553 A1, Aug. 3, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/055 (2006.01); G01R 33/341 (2006.01); G01R 33/36 (2006.01); G01R 33/60 (2006.01); G01V 3/10 (2006.01)
CPC A61B 5/055 (2013.01) [G01R 33/341 (2013.01); G01R 33/3607 (2013.01); G01R 33/3621 (2013.01); G01R 33/60 (2013.01); G01V 3/104 (2013.01)] 21 Claims
OG exemplary drawing
 
1. An apparatus for electron paramagnetic resonance oxygen imaging (EPROI) of a volume of animal tissue in vivo, the apparatus comprising:
a magnetic-field generator configured to generate a substantially static magnetic field in the volume of animal tissue;
a set of transmit coils, wherein the set of transmit coils transmit RF pulses that generate an excitation magnetic field in the volume of animal tissue in response to an applied electrical signal; and
a set of receive coils, wherein the set of receive coils generates a sensed electrical signal in response to a sensed magnetic field in the volume of animal tissue, wherein the set of receive coils is configured to detect electron paramagnetic resonance signals in the volume of animal tissue and wherein the set of transmit coils and the set of receive coils are high-isolation coils configured to reduce the reception of the transmitted RF pulses by the receive coils;
a pulsed-RF driver circuit, operatively coupled to the set of transmit coils, that drives a plurality of pulse sets, wherein each pulse set has a plurality of successive transmitted pulses, including a first pulse having a plurality of cycles of RF, followed by a first delay and thereafter by a second pulse that includes a plurality of cycles of RF; and
an RF receiver circuit operatively coupled to the set of receive coils to receive the sensed electrical signal from the set of receive coils and to generate a received electrical signal, wherein the transmitted pulses are of magnitudes and durations configured to measure an electron T1e spin-lattice relaxation in the volume of tissue in order to measure oxygen in the volume of tissue.