US 12,232,846 B2
Optical imaging or spectroscopy systems and methods
Elizabeth Marjorie Clare Hillman, New York, NY (US); and Sean A. Burgess, New York, NY (US)
Assigned to The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed by The Trustees of Columbia University in the City of New York, New York, NY (US)
Filed on Apr. 14, 2023, as Appl. No. 18/134,805.
Application 18/134,805 is a division of application No. 17/462,824, filed on Aug. 31, 2021, granted, now 11,653,834.
Application 17/462,824 is a division of application No. 15/915,180, filed on Mar. 8, 2018, granted, now 11,109,758, issued on Sep. 7, 2021.
Application 15/915,180 is a continuation of application No. 15/087,979, filed on Mar. 31, 2016, abandoned.
Application 15/087,979 is a continuation of application No. 12/655,325, filed on Dec. 29, 2009, granted, now 9,655,523, issued on May 23, 2017.
Application 12/655,325 is a continuation of application No. PCT/US2008/008081, filed on Jun. 27, 2008.
Claims priority of provisional application 61/130,904, filed on Jun. 4, 2008.
Claims priority of provisional application 61/000,792, filed on Oct. 29, 2007.
Claims priority of provisional application 60/937,724, filed on Jun. 29, 2007.
Prior Publication US 2023/0255493 A1, Aug. 17, 2023
Int. Cl. A61B 5/00 (2006.01); G01J 3/28 (2006.01); G01J 3/42 (2006.01); G01J 3/457 (2006.01); G02B 23/24 (2006.01); G02B 26/10 (2006.01)
CPC A61B 5/0064 (2013.01) [A61B 5/0066 (2013.01); A61B 5/0071 (2013.01); A61B 5/0073 (2013.01); A61B 5/0075 (2013.01); A61B 5/444 (2013.01); A61B 5/445 (2013.01); G01J 3/2889 (2013.01); G01J 3/42 (2013.01); G01J 3/457 (2013.01); G02B 23/2476 (2013.01); G02B 26/101 (2013.01); A61B 5/0088 (2013.01); A61B 2562/0238 (2013.01); A61B 2562/0242 (2013.01)] 8 Claims
OG exemplary drawing
 
1. An imaging method, comprising:
scanning an excitation beam through an objective lens causing a point of incidence of the excitation beam to move across a target;
using the objective lens to capture image light caused by optical responses induced by the excitation beam;
imaging captured image light corresponding to a region of interest of the target onto a light detector;
the imaging including de-scanning the image light so that the region of interest moves with the point of incidence thereby holding the image's position on the light detector;
the scanning and de-scanning including positioning a beam splitter to direct the excitation beam towards the objective lens and direct the image light from the objective lens such that the image light and the excitation beam can be deflected by a moving deflector element.