US 11,906,528 B2
Kits and methods to distinguish false labor and true labor
Adi L. Tarca, South Lyon, MI (US); Piya Chaemsaithong, Shatin (HK); Tinnakorn Chaiworapongsa, Grosse Pointe Park, MI (US); Sonia S. Hassan, Novi, MI (US); and Roberto Romero, Grosse Pointe, MI (US)
Assigned to Wayne State University, Detroit, MI (US); and The United States of America, as Represented by the Secretary, Department of Health & Human Services, Bethesda, MD (US)
Filed by Wayne State University, Detroit, MI (US); and The United States of America, as Represented by the Secretary, Department of Health & Human Service, Bethesda, MD (US)
Filed on Nov. 12, 2021, as Appl. No. 17/525,717.
Application 17/525,717 is a division of application No. 15/773,980, granted, now 11,204,354, previously published as PCT/US2016/060819, filed on Nov. 7, 2016.
Claims priority of provisional application 62/251,517, filed on Nov. 5, 2015.
Prior Publication US 2022/0065867 A1, Mar. 3, 2022
Int. Cl. G01N 33/53 (2006.01); G01N 33/543 (2006.01); G01N 33/68 (2006.01); G06F 17/18 (2006.01); G16B 5/00 (2019.01); G16B 5/20 (2019.01)
CPC G01N 33/689 (2013.01) [G01N 33/543 (2013.01); G06F 17/18 (2013.01); G16B 5/00 (2019.02); G16B 5/20 (2019.02); C12Y 101/01205 (2013.01); C12Y 504/02 (2013.01); G01N 2333/4727 (2013.01); G01N 2800/368 (2013.01)] 19 Claims
 
1. A method, comprising:
obtaining a sample from a pregnant female experiencing symptoms associated with false labor and true labor; and
measuring in the sample for abundance of:
(i) tissue factor (TF), ICOS Ligand (B7-H2), VPS10 Domain Containing Receptor SorCS2 (SORC2), and Plasma Protease C1 Inhibitor (C1-Esterase Inhibitor); or
(ii) TF, Ras-related Nuclear protein (Ran), Inosine-5′-monophosphate dehydrogenase (IMDH1), and Phosphoglycerate mutase 1 (PGAM1).