US 11,905,338 B2
Peptides for use as cell-penetrating peptides
Sébastien Deshayes, Montpellier (FR); Karidia Konate, Montpellier (FR); Eric Vives, Castelnau le Lez (FR); Gudrun Aldrian, Prades-le-Lez (FR); and Prisca Boisguerin, Montpellier (FR)
Assigned to CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and UNIVERSITÉ DE MONTPELLIER, Montpellier (FR)
Appl. No. 17/260,244
Filed by CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris (FR); and UNIVERSITE DE MONTPELLIER, Montpellier (FR)
PCT Filed Jul. 16, 2019, PCT No. PCT/EP2019/069149
§ 371(c)(1), (2) Date Jan. 14, 2021,
PCT Pub. No. WO2020/016242, PCT Pub. Date Jan. 23, 2020.
Claims priority of application No. 18183966 (EP), filed on Jul. 17, 2018.
Prior Publication US 2021/0292364 A1, Sep. 23, 2021
Int. Cl. C07K 7/08 (2006.01); A61K 9/51 (2006.01); C12N 15/113 (2010.01)
CPC C07K 7/08 (2013.01) [A61K 9/5169 (2013.01); C12N 15/1137 (2013.01); C12N 2310/14 (2013.01); C12N 2320/32 (2013.01)] 17 Claims
 
1. A non-naturally occurring cell penetrating peptide that is 14 to 16 amino acid residues in length and has an amino acid sequence of LL-[X]n-LL, wherein X is selected from R, L and W, and n=10 to 12, and wherein [X]n contains 4 R, 4 L and between 2 and 4 W amino acid residues.